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Article

Detecting mitochondrial mutations associated with aminoglycoside ototoxicity by noninvasive prenatal testing.

Journal of clinical laboratory analysis - 1 Jan 2023

Huang Quanfei, Liu Yanhui, Lei Wei, Liang Jiajie, Wang Yang, Zheng Minhua, Huang Xiaoyan, Liu Yuanru, Huang Kaisheng, Huang Min

Abstract excerpt

OBJECTIVES: Numerous diseases and disorders are associated with mitochondrial DNA (mtDNA) mutations, among which m.1555A > G and m.1494C > T mutations in the 12 S ribosomal RNA gene contribute to aminoglycoside-induced and nonsyndromic hearing loss worldwide. METHODS: A total of 76,842 qualified non-invasive prenatal (NIPT) samples were subjected to mtDNA mutation and haplogroup analysis. RESULTS: We detected...

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Identifiers

PMID: 36579624
DOI: 10.1002/jcla.24827
PMCID: PMC9833975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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