Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity.

doi:10.1016/j.mito.2010.10.006

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Article

Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity.

Mitochondrion - 1 Mar 2011

Guan Min-Xin

Abstract excerpt

The mitochondrial 12S rRNA is a hot spot for mutations associated with both aminoglycoside-induced and nonsyndromic hearing loss. Of those, the homoplasmic 1555A>G and 1494C>T mutations at the highly conserved decoding region of the 12S rRNA have been associated with hearing loss worldwide. In particular, these two mutations account for a significant number of cases of aminoglycoside ototoxicity. The 1555A>G or...

Topics

Aminoglycosides
Carbohydrate Sequence
Hearing Loss
Humans
Mitochondria
Molecular Epidemiology
Molecular Sequence Data
Mutation
RNA, Ribosomal

Source

Open in PubMed

Identifiers

PMID: 21047563
DOI: 10.1016/j.mito.2010.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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