Article
Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis.
Journal of medical genetics - 1 Feb 2015
Jing Wu, Zongjie Hao, Denggang Fu, Na Hei, Bin Zhang, Aifen Zhou, Xijiang Hu, Cong Yao, Yunping Dong, Ring Huijun Z, Ring Brian Z
Abstract excerpt
BACKGROUND: Genetic variations, including mitochondrial mutations, are important contributors to hearing loss, especially in children, and newborn genetic screens for hearing loss mutations are becoming increasingly common. Mitochondrial mutations have been linked with ototoxic responses to common antibiotics, therefore understanding the association of these mutations with hearing loss is of special importance....
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