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Article

Inherited susceptibility to aminoglycoside ototoxicity: genetic heterogeneity and clinical implications.

American journal of otolaryngology - 1 Jan 2000

Casano R A, Johnson D F, Bykhovskaya Y, Torricelli F, Bigozzi M, Fischel-Ghodsian N

Abstract excerpt

PURPOSE: Aminoglycoside-induced ototoxicity appears to have a genetic susceptibility in some individuals, and the A1555G mutation in the mitochondrial 12S ribosomal RNA gene has been shown to be responsible for this susceptibility in all familial cases. An Italian family with 5 family members who became deaf after aminoglycoside exposure presented to us, and molecular analysis excluded the A1555G mutation. The...

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Identifiers

PMID: 10326749
DOI: 10.1016/s0196-0709(99)90062-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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