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Article

HLA-DQB1*06:02 and a critical amino acid variant in protection against occult hepatitis B virus infection.

Frontiers in immunology - 1 Jan 2026

Wu Mimi, Pi Wenwen, Li Qi, He Yizhen, Yu Guangshu, Zhu Hong, Wu Zhipan, He Ji, He Yanmin, Zhu Faming

Abstract excerpt

The human leukocyte antigen (HLA) system plays a critical role in determining the outcomes of hepatitis B virus (HBV) infection, yet the genetic mechanisms underlying occult HBV infection (OBI), a form marked by detectable HBV DNA in the absence of hepatitis B surface antigen, remain poorly defined. Here, we performed high-resolution HLA genotyping and amino acid-based association analysis in a Chinese population...

Read the complete abstract on PubMed

Topics

Humans
HLA-DQ beta-Chains
Hepatitis B virus
Genetic Predisposition to Disease
Hepatitis B
Haplotypes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Alleles

Genotype

Male

Amino Acid Substitution

Source

Open in PubMed Open full text

Identifiers

PMID: 42682600
DOI: 10.3389/fimmu.2026.1898993
PMCID: PMC13529657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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