HLA-B Serine 116 Confers Protection Against Severe COVID-19 in a Cohort From Rio de Janeiro, Brazil.

doi:10.1111/tan.70479

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HLA-B Serine 116 Confers Protection Against Severe COVID-19 in a Cohort From Rio de Janeiro, Brazil.

HLA - 1 Dec 2025

Pereira Maria Aparecida da Silva, Ferreira Sâmila Natiane, Gonçalves Cássia Cristina Alves, Reis Mirella Carneiro Dos, Zampier Carolina da Paz, Leitão Isabela de Carvalho, Lopes Monique de Souza Almeida, Rossi Artur Duque, Soares-Lima Sheila Coelho, Galliez Rafael Mello, Barroso Shana Priscila Coutinho, Junior Orlando da Costa Ferreira, Tanuri Amilcar, Castiñeiras Terezinha Marta Pereira Pinto, Rossi Átila Duque, Cardoso Cynthia Chester

Abstract excerpt

COVID-19 is a respiratory disease caused by SARS-CoV-2, in which severe outcomes are primarily driven by an exacerbated immune response. The HLA region has been extensively investigated in COVID-19 due to its central role in the immune response, although genetic associations vary across populations. Here, the association of HLA genetic variability with COVID-19 severe respiratory outcomes was investigated in an...

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Topics

Humans
COVID-19
Brazil
SARS-CoV-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Serine

Alleles

Middle Aged

Severity of Illness Index

HLA-B Antigens

Adult

Cohort Studies

HLA-DP beta-Chains

Genetic Predisposition to Disease

Source

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Identifiers

PMID: 41314220
DOI: 10.1111/tan.70479
PMCID: PMC12662660

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