Article
Genome-wide association study identifies HLA-DR variants conferring risk of HBV-related acute-on-chronic liver failure.
Gut - 1 Apr 2018
Tan Wenting, Xia Jie, Dan Yunjie, Li Mengying, Lin Shide, Pan Xingnan, Wang Huifen, Tang Yingzi, Liu Nana, Tan Shun, Liu Ming, He Weiwei, Zhang Weihua, Mao Qing, Wang Yuming, Deng Guohong
Abstract excerpt
OBJECTIVE: Acute-on-chronic liver failure (ACLF) is an extreme condition after severe acute exacerbation of chronic hepatitis B; however, the underlying genetic factors involved in its onset and progression are currently unclear. DESIGN: We carried out a genome-wide association study among 399 HBV-related ACLFs (cases) and 401 asymptomatic HBV carriers (AsCs, as controls) without antiviral treatment. The initial...
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