Article

A genetic screen to uncover molecular mechanisms underlying lipid transfer protein function at membrane contact sites and neurodegeneration

2023-07-29

Abstract excerpt

Lipid transfer proteins mediate the transfer of lipids between organelle membranes in eukaryotes and loss of function in these has been linked to neurodegenerative disorders. However, the mechanism by which loss of lipid transfer protein function leads to neurodegeneration is not understood. In Drosophila photoreceptors, depletion of Retinal Degeneration B (RDGB), a phosphatidylinositol transfer protein localized...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 44360346-b933-52c7-926f-09f953e14713
DOI: 10.1101/2023.07.28.550979

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genetic screen to uncover molecular mechanisms underlying lipid transfer protein function at membrane contact sites and neurodegenerationDOI 10.1101/2023.07.28.550979Read

Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype.Semantic proximity Read

Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerationsSemantic proximity Read

Localization of Drosophila retinal degeneration B, a membrane-associated phosphatidylinositol transfer protein.Semantic proximity Read

RDS Functional Domains and Dysfunction in Disease.Semantic proximity Read

A Neuronal-specific Mammalian Homolog of theDrosophilaRetinal Degeneration B Gene with Expression Restricted to the Retina and Dentate GyrusSemantic proximity Read

A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen.Semantic proximity Read

Drosophila fabp is required for light-dependent Rhodopsin-1 clearance and photoreceptor survival.Semantic proximity Read

VPS13A and VPS13C influence lipid droplet abundanceSemantic proximity Read

Neuro-glial lipid imbalance in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis 8Semantic proximity Read

Bridge-like lipid transfer protein family member 2 suppresses ciliogenesisSemantic proximity Read

TULP1 missense mutations cause variable retinal phenotypes and activation of the endoplasmic reticulum unfolded protein response pathway.Semantic proximity Read

Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 miceSemantic proximity Read