Intracellular trafficking of ceramide by ceramide transfer protein.

doi:10.2183/pjab.86.426

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Article

Intracellular trafficking of ceramide by ceramide transfer protein.

Proceedings of the Japan Academy. Series B, Physical and biological sciences - 1 Jan 2010

Hanada Kentaro

Abstract excerpt

The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin. Ceramide transfer protein (CERT) mediates the ER-to-Golgi trafficking of ceramide. It has been suggested that CERT extracts...

Topics

Animals
Biological Transport
Ceramides
Humans
Intracellular Space
Mutation
Neoplasms
Protein Serine-Threonine Kinases

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Identifiers

PMID: 20431265
DOI: 10.2183/pjab.86.426
PMCID: PMC3417804

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