Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development.

Developmental cell - 1 Oct 2003

Weber Ursula, Eroglu Cagla, Mlodzik Marek

Abstract excerpt

The role of phospholipids in the regulation of membrane trafficking and signaling is largely unknown. Phosphatidylcholine (PC) is a main component of the plasma membrane. Mutants in the Drosophila phosphocholine cytidylyltransferase 1 (CCT1), the rate-limiting enzyme in PC biosynthesis, show an altered phospholipid composition with reduced PC and increased phosphatidylinositol (PI) levels. Phenotypic features of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, Thin Layer
Share to Clathrin
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Abnormalities

Share to Insect Proteins

Share to Phospholipids

Share to Receptors, Notch

Share to Subcellular Fractions

Source

Identifiers

PMID: 14536058
DOI: 10.1016/s1534-5807(03)00273-9

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development.PMID 14536058Read ↗

Disruption of Drosophila melanogaster lipid metabolism genes causes tissue overgrowth associated with altered developmental signaling.Semantic proximity Read ↗

Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis.Semantic proximity Read ↗

Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration.Semantic proximity Read ↗

A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasisSemantic proximity Read ↗

Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects.Semantic proximity Read ↗

Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.Semantic proximity Read ↗

dOCRL maintains immune cell quiescence by regulating endosomal traffic.Semantic proximity Read ↗

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.Semantic proximity Read ↗

Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafishSemantic proximity Read ↗

A <i>pcyt-1</i> Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in <i>C. elegans</i>Semantic proximity Read ↗

A pcyt-1 allelic series reveals in vivo consequences of reduced phosphatidylcholine synthesis in C. elegans.Semantic proximity Read ↗

Glycosylphosphatidylinositol Biosynthesis and Remodeling are Required for Neural Crest Cell, Cardiac and Neural DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.