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Article

Genomic and transcriptomic characterization of heterogeneous immune subgroups of microsatellite instability-high colorectal cancers.

Journal for immunotherapy of cancer - 1 Dec 2021

Kim Jung Ho, Seo Mi-Kyoung, Lee Ji Ae, Yoo Seung-Yeon, Oh Hyeon Jeong, Kang Hyundeok, Cho Nam-Yun, Bae Jeong Mo, Kang Gyeong Hoon, Kim Sangwoo

Abstract excerpt

BACKGROUND: Colorectal cancers (CRCs) with microsatellite instability-high (MSI-H) are hypermutated tumors and are generally regarded as immunogenic. However, their heterogeneous immune responses and underlying molecular characteristics remain largely unexplained. METHODS: We conducted a retrospective analysis of 73 primary MSI-H CRC tissues to characterize heterogeneous immune subgroups. Based on combined...

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Identifiers

PMID: 34903553
DOI: 10.1136/jitc-2021-003414
PMCID: PMC8672019

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