Article
Hereditary Diffuse Gastric Cancer With Poorly Differentiated Gallbladder Adenocarcinoma: A Case Report Suggesting Carcinogenesis in the Stomach and Gallbladder Caused by a Pathogenic Germline Variant in CDH1.
In vivo (Athens, Greece) - 1 Jan 2026
Hayashi Masato, Kubota Naoto, Abe Makoto, Ishii Masatsugu, Sasaki Kazuki, Ando Miho, Sugano Kokichi, Yoshida Teruhiko, Hirata Makoto, Sugimura Haruhiko
Abstract excerpt
BACKGROUND/AIM: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome primarily characterized by a high lifetime risk of diffuse gastric cancer and lobular breast cancer. It is predominantly caused by inactivating germline variants in the tumor suppressor gene CDH1. While the association between HDGC and these two specific malignancies is well-established, the co-occurrence of...
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