Computational Analysis of Sequence Editability in the Theophylline RNA Aptamer as a Functional RNA Module.

Abstract excerpt

RNA aptamers are often used as ligand-recognition modules in engineered RNA systems, but integration into larger RNA constructs can influence stability and ligand binding. As a result, aptamer sequences may need to be adapted to new environments while preserving essential properties. Here, we examine this sequence editability problem for the theophylline RNA aptamer. Starting from the experimentally determined...

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