Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular interactions and metal binding in the theophylline-binding core of an RNA aptamer.

RNA (New York, N.Y.) - 1 May 2000

Zimmermann G R, Wick C L, Shields T P, Jenison R D, Pardi A

Abstract excerpt

An RNA aptamer containing a 15-nt binding site shows high affinity and specificity for the bronchodilator theophylline. A variety of base modifications or 2' deoxyribose substitutions in binding-site residues were tested for theophyllinebinding affinity and the results were compared with the previously determined three-dimensional structure of the RNA-theophylline complex. The RNA-theophylline complex contains a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchodilator Agents
Share to Caffeine
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Spectroscopy

Share to Metals

Share to Nucleic Acid Conformation

Share to Theophylline

Source

Open in PubMed Open full text

Identifiers

PMID: 10836787
DOI: 10.1017/s1355838200000169
PMCID: PMC1369946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular interactions and metal binding in the theophylline-binding core of an RNA aptamer.PMID 10836787Read ↗

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain.Semantic proximity Read ↗

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch.Semantic proximity Read ↗

Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition.Semantic proximity Read ↗

Solution structure of an ATP-binding RNA aptamer reveals a novel fold.Semantic proximity Read ↗

Recognition of planar and nonplanar ligands in the malachite green-RNA aptamer complex.Semantic proximity Read ↗

Quadruplex-Flanking Stem Structures Modulate the Stability and Metal Ion Preferences of RNA Mimics of GFP.Semantic proximity Read ↗

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain.Semantic proximity Read ↗

Effects of Mg2+ on the free energy landscape for folding a purine riboswitch RNA.Semantic proximity Read ↗

Design of an adenosine analogue that selectively improves the affinity of a mutant U1A protein for RNA.Semantic proximity Read ↗

An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integraseSemantic proximity Read ↗

Use of a novel Förster resonance energy transfer method to identify locations of site-bound metal ions in the U2-U6 snRNA complex.Semantic proximity Read ↗

Defining the secondary structural requirements of a cocaine-binding aptamer by a thermodynamic and mutation study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.