Population-Specific Genetic Markers of Prostate Cancer Risk in Kazakh Men: Association Analysis of 102 SNPs and Risk Prediction Modeling.

doi:10.3390/genes17080956

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Population-Specific Genetic Markers of Prostate Cancer Risk in Kazakh Men: Association Analysis of 102 SNPs and Risk Prediction Modeling.

Genes - 14 Aug 2026

Kazbekov Kairat, Zhapparov Yerbol, Shanazarov Nasrulla, Benberin Valery, Zinchenko Sergey, Kazbekova Ainagul

Abstract excerpt

BACKGROUND/OBJECTIVES: GWASs have identified more than 250 prostate cancer (PCa) predisposition loci, predominantly in European and partly Asian cohorts. The Kazakh population is markedly under-represented in international genetic studies, limiting existing risk models. This study aimed to analyze the distribution of 102 PCa-associated single-nucleotide polymorphism (SNP) genotypes and alleles and to identify...

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PMID: 42650149
DOI: 10.3390/genes17080956
PMCID: PMC13512394

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