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Article

Polygenic risk and germline genetics for prostate cancer in Asians: Where do we stand?

Investigative and clinical urology - 1 Mar 2026

Song Sang Hun, Hong Sung Kyu

Abstract excerpt

Prostate cancer exhibits marked ethnic differences in genetic architecture. Although polygenic risk scores (PRS) and germline genetic testing have shown clinical utility in European populations, their applicability to Asian populations remains limited. This review synthesizes evidence published between 2020 and 2025 on PRS and germline genetics in Asian prostate cancer cohorts, focusing on Chinese, Japanese, and...

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Asian People
HOXB13 gene
Genetic Predisposition to Disease
Genetic Risk Score
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Multifactorial Inheritance

Prostatic Neoplasms

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Identifiers

PMID: 41775441
DOI: 10.4111/icu.20250694
PMCID: PMC12956768

Genes

BRCA2
HOXB13

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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