Characterization of SNPs associated with prostate cancer in men of Ashkenazic descent from the set of GWAS identified SNPs: impact of cancer family history and cumulative SNP risk prediction.

doi:10.1371/journal.pone.0060083

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Article

Characterization of SNPs associated with prostate cancer in men of Ashkenazic descent from the set of GWAS identified SNPs: impact of cancer family history and cumulative SNP risk prediction.

PloS one - 1 Jan 2013

Agalliu Ilir, Wang Zhaoming, Wang Tao, Dunn Anne, Parikh Hemang, Myers Timothy, Burk Robert D, Amundadottir Laufey

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified multiple SNPs associated with prostate cancer (PrCa). Population isolates may have different sets of risk alleles for PrCa constituting unique population and individual risk profiles. METHODS: To test this hypothesis, associations between 31 GWAS SNPs of PrCa were examined among 979 PrCa cases and 1,251 controls of Ashkenazic descent using...

Topics

Alleles
Area Under Curve
Case-Control Studies
Chromosomes, Human
Gene Frequency
Genome-Wide Association Study
Humans
Jews
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Odds Ratio

Pedigree

Polymorphism, Single Nucleotide

Prostatic Neoplasms

ROC Curve

Risk

Sequence Analysis, DNA

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Open in PubMed Open full text

Identifiers

PMID: 23573233
DOI: 10.1371/journal.pone.0060083
PMCID: PMC3616024

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