Article
Performance of Three Inherited Risk Measures for Predicting Prostate Cancer Incidence and Mortality: A Population-based Prospective Analysis.
European urology - 1 Mar 2021
Shi Zhuqing, Platz Elizabeth A, Wei Jun, Na Rong, Fantus Richard J, Wang Chi-Hsiung, Eggener Scott E, Hulick Peter J, Duggan David, Zheng S Lilly, Cooney Kathleen A, Isaacs William B, Helfand Brian T, Xu Jianfeng
Abstract excerpt
BACKGROUND: Single nucleotide polymorphism-based genetic risk score (GRS) has been developed and validated for prostate cancer (PCa) risk assessment. As GRS is population standardized, its value can be interpreted as a relative risk to the general population. OBJECTIVE: To compare the performance of GRS with two guideline-recommended inherited risk measures, family history (FH) and rare pathogenic mutations...
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