Article
How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis.
Clinical genitourinary cancer - 1 Apr 2023
Siltari Aino, Lönnerbro Ragnar, Pang Karl, Shiranov Kirill, Asiimwe Alex, Evans-Axelsson Susan, Franks Billy, Kiran Amit, Murtola Teemu J, Schalken Jack, Steinbeisser Carl, Bjartell Anders, Auvinen Anssi
Abstract excerpt
OBJECTIVES: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. PATIENTS AND METHODS: Data were extracted from 59 studies, with 16 studies including 17...
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