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Article

Exome-based cancer driver gene comprehensive testing can provide a genetic diagnosis for individuals with triple-negative breast cancer.

PloS one - 1 Jan 2026

Alzate Daniel, Sánchez Angel Yobany, Pacheco Yovana, Isaza Ruget Mario, Sánchez Ramiro, Castillo Carolina, Parra-López Carlos A

Abstract excerpt

Triple-negative breast cancer (TNBC) is characterized by aggressive behaviour, high tumor heterogeneity, and an increased likelihood of recurrence and early metastasis. These factors hinder successful treatment. Genetic diagnosis enables personalized clinical recommendations and treatment options. The objective of this study was to validate whole-exome sequencing (WES) and variant prioritization in cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42636242
DOI: 10.1371/journal.pone.0356762
PMCID: PMC13502651

Genes

ATM
BRCA1
RAD51D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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