Article
Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.
The FEBS journal - 1 Sept 2015
Aloraifi Fatima, McDevitt Trudi, Martiniano Rui, McGreevy Jonah, McLaughlin Russell, Egan Chris M, Cody Nuala, Meany Marie, Kenny Elaine, Green Andrew J, Bradley Daniel G, Geraghty James G, Bracken Adrian P
Abstract excerpt
The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 enhanced clinicians' ability to select high-risk individuals for aggressive surveillance and prevention, and led to the development of targeted therapies. However, BRCA1/2 mutations account for only 25% of familial breast cancer cases. To systematically identify rare, probably pathogenic variants in familial cases of breast cancer...
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