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Exploring the hereditary genetic mutational landscape of breast and ovarian cancer in Estonia.

Scientific reports - 13 Mar 2026

Tooming Mikk, Toome Kadri, Rekker Kadri, Roht Laura, Laidre Piret, Fjodorova Olga, Roomere Hanno, Murumets Ülle, Šamarina Ustina, Pajusalu Sander, Žordania Riina, Tael Kristi, Vaidla Eve, Kurvinen Elvira, Tõnisson Neeme, Ilisson Mihkel, Padrik Peeter, Lehtsaar Jaak, Kütner Riina, Vettus Elen, Vahar Helen, Peets Pilleriin, Õunap Katrin, Kahre Tiina

Abstract excerpt

Germline genetic testing (GT) of cancer-associated genes enables the identification of hereditary risk in breast (BC) and ovarian cancer (OC) patients, supporting early diagnosis and personalized treatment strategies. In this study, we analyzed data from 3,537 patients who underwent routine clinical GT in Estonia between 2007–2023, including 2,856 BC and 759 cases of OC. A total of 78 individuals in the study...

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Source

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Identifiers

PMID: 41826624
DOI: 10.1038/s41598-026-43459-y
PMCID: PMC13106779

Genes

BRCA1
BRCA2
CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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