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Article

L Antigen Family Member 3 stabilizes stalled replication forks by reducing MRE11 resection to maintain genome stability.

Nucleic acids research - 24 Aug 2026

Lyu Meng, Yang Guihua, Jia Shaopeng, Zhang Xiangze, Li Yingzheng, Feng Yujing, Lyu Xinxing

Abstract excerpt

L Antigen Family Member 3 (LAGE3) is a core component of the KEOPS complex, mutations of which are implicated in Galloway-Mowat syndrome (GAMOS). The KEOPS complex is known to function in telomere maintenance and tRNA N6-threonylcarbamoyladenosine (t6A) modification. However, whether the KEOPS complex also contributes to chromosomal DNA regulation through additional mechanisms remains elusive. Here, we find that...

Topics

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DNA Replication
MRE11 gene
Genomic Instability
MRE11 Homologue Protein
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42635129
DOI: 10.1093/nar/gkag842
PMCID: PMC13501129

Genes

LAGE3
MRE11
TP53RK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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