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Article

L Antigen Family Member 3 stabilizes stalled replication forks by reducing MRE11 resection to maintain genome stability.

Nucleic acids research - 24 Aug 2026

Lyu Meng, Yang Guihua, Jia Shaopeng, Zhang Xiangze, Li Yingzheng, Feng Yujing, Lyu Xinxing

Abstract excerpt

L Antigen Family Member 3 (LAGE3) is a core component of the KEOPS complex, mutations of which are implicated in Galloway-Mowat syndrome (GAMOS). The KEOPS complex is known to function in telomere maintenance and tRNA N6-threonylcarbamoyladenosine (t6A) modification. However, whether the KEOPS complex also contributes to chromosomal DNA regulation through additional mechanisms remains elusive. Here, we find that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42635129
DOI: 10.1093/nar/gkag842
PMCID: PMC13501129

Genes

LAGE3
MRE11
TP53RK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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L Antigen Family Member 3 stabilizes stalled replication forks by reducing MRE11 resection to maintain genome stability.PMID 42635129Read ↗

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Orc6 is a component of the replication fork and enables efficient mismatch repairSemantic proximity Read ↗

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