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Article

Delineating SWI/SNF gene and subtype expression in cancer.

Epigenetics & chromatin - 20 Aug 2026

Canfjorden Vilma, Lindén Malin, Österlund Tobias, Larsson Erik, Ståhlberg Anders

Abstract excerpt

BACKGROUND: Approximately 20% of all cancers contain mutations in genes coding for components of the SWI/SNF chromatin remodeling complex, which exists in three main subtypes: cBAF, PBAF, and GBAF. Mutations in SWI/SNF genes may disrupt chromatin remodeling and deregulate epigenetic processes, leading to aberrant gene expression profiles. However, the gene expression profiles of SWI/SNF genes and subtypes across...

Topics

Humans
Neoplasms
Gene Expression Regulation, Neoplastic
Chromosomal Proteins, Non-Histone
Transcription Factors
Mutation
Chromatin Assembly and Disassembly

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 42629553
DOI: 10.1186/s13072-026-00696-9
PMCID: PMC13495434

Genes

ACTL6B
DPF1
DPF3
SMARCD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-42629553-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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