Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Current status and relevance of single nucleotide polymorphisms in IL-6-/IL-12-type cytokine receptors.

Cytokine - 1 Dec 2021

Scheller Jürgen, Berg Anna, Moll Jens M, Floss Doreen M, Jungesblut Christopher

Abstract excerpt

Cytokines control immune related events and are critically involved in a plethora of patho-physiological processes including autoimmunity and cancer development. In rare cases, single nucleotide polymorphisms (SNPs) or single nucleotide variations (SNVs) in cytokine receptors eventually cause detrimental ligand-independent, constitutive activation of signal transduction. Most SNPs have, however, no or only...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interleukin-12
Share to Interleukin-6
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Cytokine

Source

Identifiers

PMID: 34217594
DOI: 10.1016/j.cyto.2021.155550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Current status and relevance of single nucleotide polymorphisms in IL-6-/IL-12-type cytokine receptors.PMID 34217594Read ↗

Cytokine and cytokine receptor gene polymorphisms and their functionality.Semantic proximity Read ↗

IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological FunctionsSemantic proximity Read ↗

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs).Semantic proximity Read ↗

Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.Semantic proximity Read ↗

Differential Associations of Interleukin 6 Receptor Variant Across Genetic Ancestries and Implications for Targeted TherapiesSemantic proximity Read ↗

IL-12Rβ1 deficiency: mutation update and description of the IL12RB1 variation database.Semantic proximity Read ↗

Disease associated cytokine SNPs database: an annotation and dissemination model.Semantic proximity Read ↗

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.Semantic proximity Read ↗

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.Semantic proximity Read ↗

Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity.Semantic proximity Read ↗

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.Semantic proximity Read ↗

CytoSIP: An annotated structural atlas for interactions involving cytokine or cytokine receptorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.