Article
Effect of IL-6 C-572G polymorphism on idiopathic membranous nephropathy risk in a Han Chinese population.
Renal failure - 1 Jan 2010
Chen Shih-Yin, Chen Cheng-Hsu, Huang Yu-Chuen, Chuang Hsuan-Min, Lo Ming-Min, Tsai Fuu-Jen
Abstract excerpt
Membranous glomerulonephritis (MGN) is viewed as an immune-mediated glomerular disease, with immunologic expression occurring in genetically susceptible persons. The cytokine interleukin-6 (IL-6) gene polymorphism is known to impair intracellular signaling pathways following adaptive immune response. Our study gauged the effects of IL-6 C-572G (rs1800796) single nucleotide polymorphism (SNP) on MGN among Taiwan's...
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