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Article

Excessive disulfide bonds in lamin A/C contribute to premature human aging.

Molecules and cells - 1 Oct 2026

Ha Seokjun G, Park Minho, Lee Jinwook, Bong Dajeong, Ahn Jinsook, Kim Doyeon, Kim Myung-Ok, Lee Seung-Jae V, Ha Nam-Chul

Abstract excerpt

Nuclear lamins provide structural integrity to the nuclear envelope through coiled-coil dimer meshworks. Lamin A contains a C-terminal immunoglobulin (Ig)-like domain and a cysteine-rich unstructured tail, whereas lamin C lacks the latter, retaining only 1 cysteine within the Ig-like domain. Mutations R435C and R471C in the Ig-like domain are linked to progeroid syndromes, fatal disorders characterized by...

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Topics

Humans
Lamin Type A
Animals
Disulfides
Aging, Premature
Caenorhabditis elegans
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Progeria

Oxidative Stress

Source

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Identifiers

PMID: 42607812
DOI: 10.1016/j.mocell.2026.100389
PMCID: PMC13571133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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