Article
Lamin A/C, laminopathies and premature ageing.
Histology and histopathology - 1 Jun 2008
Liu Baohua, Zhou Zhongjun
Abstract excerpt
Lamin A/C belongs to type V intermediate filaments and constitutes the nuclear lamina and nuclear matrix, where a variety of nuclear activities occur. Lamin A/C protein is firstly synthesized as a precursor and is further proteolytically processed by the zinc metallo-proteinase Ste24 (Zmpste24). Lamin A/C mutations cause a series of human diseases, collectively called laminopathies, the most severe of which is...
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