Article
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation.
Aging cell - 1 Dec 2011
Pekovic Vanja, Gibbs-Seymour Ian, Markiewicz Ewa, Alzoghaibi Fahad, Benham Adam M, Edwards Robert, Wenhert Manfred, von Zglinicki Thomas, Hutchison Christopher J
Abstract excerpt
Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of age-related degenerative diseases is termed 'laminopathies'. Here, we show that mature lamin A has an essential role in cellular fitness and that oxidative damage to lamin A is involved in cellular senescence. Primary human dermal fibroblasts (HDFs) aged replicatively or by pro-oxidants acquire a range of dysmorphic nuclear...
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