Article
Involvement of prelamin A in laminopathies.
Critical reviews in eukaryotic gene expression - 1 Jan 2007
Maraldi N M, Lattanzi G
Abstract excerpt
The precursor protein of the nuclear lamina constituent lamin A is a 74-kDa protein called prelamin A which undergoes subsequent steps of posttranslational modification at its C-terminal CaaX residue. The unexpected finding that accumulation of unprocessable prelamin A is the molecular basis of the most severe laminopathies so far identified, including Hutchinson-Gilford progeria and restrictive dermopathy, has...
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