Article
Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2008
Wiesel Naama, Mattout Anna, Melcer Shai, Melamed-Book Naomi, Herrmann Harald, Medalia Ohad, Aebi Ueli, Gruenbaum Yosef
Abstract excerpt
Lamins are nuclear intermediate filament proteins and the major building blocks of the nuclear lamina. Besides providing nuclear shape and mechanical stability, lamins are required for chromatin organization, transcription regulation, DNA replication, nuclear assembly, nuclear positioning, and apoptosis. Mutations in human lamins cause many different heritable diseases, affecting various tissues and causing early...
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