Article

Multidimensional Single-Cell Transcriptomic Profiling of Uterine Leiomyosarcomas Reveals Distinct Tumor States with Inferred Therapeutic Vulnerabilities

2025-11-18

Abstract excerpt

Uterine leiomyosarcoma (ULMS) is an orphan disease that frequently recurs and metastasizes, with patients undergoing multiple lines of chemotherapy due to lack of effective therapeutic targets. To address this gap, we used single-cell RNA sequencing and spatial transcriptomic analysis to comprehensively profile ULMS. We uncovered multiple states of tumor cells, including tumor cells with mesenchyme-like features,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 202a08e5-f71c-5d4e-9118-6579fa804553
DOI: 10.1101/2025.11.17.688894

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multidimensional Single-Cell Transcriptomic Profiling of Uterine Leiomyosarcomas Reveals Distinct Tumor States with Inferred Therapeutic VulnerabilitiesDOI 10.1101/2025.11.17.688894Read

A Pan-Cancer Single-Cell Compendium of Intratumoural HeterogeneitySemantic proximity Read

A Single-Cell Atlas Reveals Cancer Cell Plasticity and Stromal-Immune Remodeling in Uterine Carcinosarcoma Across Diverse AncestriesSemantic proximity Read

Single-cell transcriptome profiles the heterogeneity of tumor cells and microenvironments for different pathological endometrial cancer and identifies specific sensitive drugsSemantic proximity Read

Mapping Human Uterine Disorders Through Single-Cell TranscriptomicsSemantic proximity Read

Integrated Transcriptomic Landscape and Deep Learning Based Survival Prediction in Uterine SarcomasSemantic proximity Read

Single-Cell Transcriptomics Reveals Tissue Architecture in Ovarian CarcinosarcomaSemantic proximity Read

A Deep Multi-Omics Integration Approach Reveals New Molecular Features of Uterine LeiomyosarcomaSemantic proximity Read

Molecular Subtypes of Uterine Leiomyosarcoma and Correlation with Clinical OutcomeSemantic proximity Read

Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell StatesSemantic proximity Read

Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilitiesSemantic proximity Read

Deciphering Human Tumor Biology by Single-Cell Expression ProfilingSemantic proximity Read

Beyond one-size-fits-all: single-cell transcriptomic signatures predict drug efficacy and reveal responder subgroups in endometriosisSemantic proximity Read