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Article

Investigating PXR (NR1I2) genetic polymorphisms as possible determinants of the magnitude of the clindamycin-rifampicin pharmacokinetic interaction.

European journal of clinical pharmacology - 15 Aug 2026

Zeller Valérie, Lu Estelle, Mimram Léo, Brinis Kamilia, Kerroumi Younes, Arnoux Armelle, Loriot Marie-Anne, Narjoz Céline, Jullien Vincent

Abstract excerpt

PURPOSE: Rifampicin is known to induce clindamycin metabolism via CYP3A4/5, but the magnitude of this interaction varies greatly from one patient to another. Because this metabolic induction results from rifampicin activation of the nuclear pregnane X receptor (PXR), the genetic polymorphisms of its NR1I2 gene and that of CYP3A4/5 might predict the risk of clindamycin underdosage when combined with rifampicin. We...

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Source

Identifiers

PMID: 42603181
DOI: 10.1007/s00228-026-04166-9

Genes

CYP3A4
NR1I2
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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