Article
Rifampicin Transport by OATP1B1 Variants.
Antimicrobial agents and chemotherapy - 21 Sept 2020
Litjens Carlijn H C, van den Heuvel Jeroen J M W, Russel Frans G M, Aarnoutse Rob E, Te Brake Lindsey H M, Koenderink Jan B
Abstract excerpt
Single nucleotide polymorphisms in the OATP1B1 transporter have been suggested to partially explain the large interindividual variation in rifampicin exposure. HEK293 cells overexpressing wild-type (WT) or OATP1B1 variants *1b, *4, *5, and *15 were used to determine the in vitro rifampicin intrinsic clearance. For OATP1B1*5 and *15, a 36% and 42% reduction in intrinsic clearance, respectively, compared to WT was...
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