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Article

Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.

Pharmacogenetics and genomics - 1 Aug 2006

Niemi Mikko, Kivistö Kari T, Diczfalusy Ulf, Bodin Karl, Bertilsson Leif, Fromm Martin F, Eichelbaum Michel

Abstract excerpt

Rifampicin (rifampin) is a potent inducer of cytochrome P450 (CYP) 3A4. It was recently identified as a substrate of the polymorphic organic anion transporting polypeptide 1B1 (OATP1B1) expressed on the sinusoidal membrane of human hepatocytes. The present study aimed to investigate the possible association of single nucleotide polymorphisms (SNP) in the SLCO1B1 gene encoding for OATP1B1 with the inducing effect...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Enzyme Induction

Share to Hydroxycholesterols

Share to Liver-Specific Organic Anion Transporter 1

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Source

Identifiers

PMID: 16847425
DOI: 10.1097/01.fpc.0000215070.52212.0e

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.PMID 16847425Read ↗

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