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Article

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 1996

Schuetz E G, Schinkel A H, Relling M V, Schuetz J D

Abstract excerpt

The P-glycoprotein (Pgp) efflux pump can influence the hepatocellular concentration of xenobiotics that are modulators and substrates of cytochrome P4503A (CYP3A). We tested the hypothesis that Pgp is a determinant of drug-inducible expression of CYP3A. The magnitude of CYP3A induction by rifampi...

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Biological Transport
Blotting, Northern
Cell Line
Cytochrome P-450 Enzyme System
Genotype
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

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Identifiers

PMID: 8633005
DOI: 10.1073/pnas.93.9.4001
PMCID: PMC39475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8633005-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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