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Article

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.

The Journal of clinical investigation - 1 Jan 2005

Pascussi Jean Marc, Robert Agnes, Nguyen Minh, Walrant-Debray Odile, Garabedian Michèle, Martin Pascal, Pineau Thierry, Saric Jean, Navarro Fréderic, Maurel Patrick, Vilarem Marie Josè

Abstract excerpt

Vitamin D controls calcium homeostasis and the development and maintenance of bones through vitamin D receptor activation. Prolonged therapy with rifampicin or phenobarbital has been shown to cause vitamin D deficiency or osteomalacia, particularly in patients with marginal vitamin D stores. Howe...

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Share to Cytochrome P-450 Enzyme System
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pregnane X Receptor

Share to Receptors, Cytoplasmic and Nuclear

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Source

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Identifiers

PMID: 15630458
DOI: 10.1172/JCI21867
PMCID: PMC539191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15630458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.PMID 15630458Read ↗

CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations.Semantic proximity Read ↗

PXR: A Xenobiotic Receptor of Diverse Function Implicated in PharmacogeneticsSemantic proximity Read ↗

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The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during EvolutionSemantic proximity Read ↗

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during EvolutionSemantic proximity Read ↗

Re: CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients with CYP24A1 Mutations.Semantic proximity Read ↗

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytesSemantic proximity Read ↗

Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.Semantic proximity Read ↗

Regulation of<i>CYP3A</i>Gene Transcription by the Pregnane X ReceptorSemantic proximity Read ↗

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.Semantic proximity Read ↗

Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptorSemantic proximity Read ↗

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