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Article

PXR haplotype clusters will affect the pharmacokinetics of ciclosporin in Chinese renal transplant recipients.

The Journal of pharmacy and pharmacology - 1 Feb 2020

Li Danying, Zhu Huaijun, Luo Xuemei, Ge Weihong

Abstract excerpt

OBJECTIVE: PXR was reported to be the key nuclear receptor regulating the expression of metabolizing enzymes and transporters. The aim of this study was to evaluate the influence of PXR haplotype clusters on ciclosporin concentration in Chinese renal transplant recipients during the early stage after transplantation. METHODS: A total of 98 recipients receiving ciclosporin were genotyped by PCR-RFLP, and the...

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PMID: 31820434
DOI: 10.1111/jphp.13206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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