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Article

Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers.

Antimicrobial agents and chemotherapy - 1 Dec 2018

Benefield Russell J, Slechta E Susan, Gast Christopher M, Spivak Emily S, Hanson Kimberly E, Alexander Donald P

Abstract excerpt

We evaluated the effects of rifampin coadministration and MDR1 single nucleotide polymorphisms on the disposition of daptomycin in twelve healthy adults. There were no significant changes from baseline in the clearance (0.53 versus 0.55 liters/h, P =1.00), volume of distribution (7.0 versus 7.2 liter, P =0.62), or half-life (9.7 versus 9.6 h, P =0.89) of daptomycin after exposure to rifampin. The tested MDR1...

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Identifiers

PMID: 30224525
DOI: 10.1128/AAC.01525-18
PMCID: PMC6256791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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