The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis.

doi:10.1038/s41398-024-03149-7

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The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis.

Translational psychiatry - 26 Oct 2024

Alameda Luis, Rodriguez Victoria, Di Forti Marta, Spinazzola Edoardo, Trotta Giulia, Arango Celso, Arrojo Manuel, Bernardo Miguel, Bobes Julio, de Haan Lieuwe, Del-Ben Cristina Marta, Gayer-Anderson Charlotte, Sideli Lucia, Jones Peter B, Kirkbride James B, La Cascia Caterina, Tripoli Giada, Ferraro Laura, La Barbera Daniele, Lasalvia Antonio, Tosato Sarah, Llorca Pierre-Michel, Menezes Paulo Rossi, van Os Jim, Rutten Bart P, Santos Jose Luis, Sanjuán Julio, Selten Jean-Paul, Szöke Andrei, Tarricone Ilaria, Tortelli Andrea, Velthorst Eva, Jongsma Hannah E, Vassos Evangelos, Quattrone Diego, Murray Robin M, Aas Monica

Abstract excerpt

Childhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the adversity-associated psychopathological signature is yet to be studied. We studied data of 583 First Episode Psychosis (FEP) cases from the EU-GEI FEP case-control study, including Polygenic risk scores for major depressive disorder (MDD-PRS), bipolar disorder (BD-PRS) and schizophrenia...

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PMID: 39461938
DOI: 10.1038/s41398-024-03149-7
PMCID: PMC11513137

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