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Article

Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study.

PloS one - 1 Jan 2016

Trotta Antonella, Iyegbe Conrad, Di Forti Marta, Sham Pak C, Campbell Desmond D, Cherny Stacey S, Mondelli Valeria, Aitchison Katherine J, Murray Robin M, Vassos Evangelos, Fisher Helen L

Abstract excerpt

A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing genetic vulnerability. Research on gene-environment interaction in psychosis has primarily focused on candidate genes, although the genetic effects are...

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PMID: 27648571
DOI: 10.1371/journal.pone.0163319
PMCID: PMC5029892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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