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Article

Purging the transcriptome for antibiotic tolerance.

Cell host & microbe - 12 Aug 2026

Teuber Carvalho João Pedro, Schultz Daniel

Abstract excerpt

In this issue of Cell Host & Microbe, Nishimoto et al. evolve S. pneumoniae under antibiotics and immune pressure, uncovering drug tolerance mutations, instead of resistance. Increased RNase activity depletes the RNA pool to avert lethal transcriptional collapse, preserving transcript fidelity and enabling a transcriptome reboot when drug subsides.

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Identifiers

PMID: 42586042
DOI: 10.1016/j.chom.2026.07.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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