Article
RNA quality control enables antibiotic tolerance.
Cell host & microbe - 12 Aug 2026
Nishimoto Andrew T, Ortiz-Marquez Juan C, Scribner Michelle R, Yu Yanying, Jia Qidong, Echlin Haley, Iverson Amy R, McKnight Abigail E, Olivero Nadia, Poole Aaron, Marr Enolia, Coggins Jordan, Rosenthal Adam, Chaguza Chrispin, Larsen Randolph K, Hatley Mark E, Isberg Ralph R, Cooper Vaughn S, van Opijnen Tim, Rosch Jason W
Abstract excerpt
Antibiotic resistance poses significant challenges, yet pathogen adaptation pathways vary. To determine how host environments affect adaptation, we experimentally evolved Streptococcus pneumoniae in mice subjected to antibiotics in the context of distinct immune states. High fitness costs of canonical resistance restrict its emergence. Instead, populations adopt context-specific adaptive strategies. While...
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