Genome-wide meta-analysis and integrative fine-mapping identify novel susceptibility loci and effector genes in psoriatic arthritis

Abstract excerpt

Psoriatic arthritis (PsA) is a complex immune-mediated inflammatory disorder affecting both the skin and musculoskeletal system. Although genome-wide association studies (GWAS) have identified multiple loci shared with psoriasis (PsO), the unique genetic architecture of PsA remains incompletely understood. To define PsA-specific genetic risk, we conducted a GWAS meta-analysis of 13,512 PsA cases and 715,639 non-Ps...

Topics

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• Arthritis, Psoriatic
• CD4-Positive T-Lymphocytes
• CD8-Positive T-Lymphocytes
• Chromosomes, Human, Pair 5
• Immunologic Memory
• Microarray Analysis
• Psoriasis
• Receptors, Interleukin

Identifiers and source

Literature Corpus work

541e1de9-6cf4-59e1-9ec0-df9c9f85fbd3

DOI

10.1101/2025.08.26.25334362