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Article

Shared genetic basis and spatial cellular atlas of psoriasis and metabolic syndrome.

PloS one - 1 Jan 2026

Liu Guo, Gong Fengjuan, Yang Guanhu, Li Yu, Ji Yanjiao, Chen Xinyue, Wang Chao, Luo Qinghua

Abstract excerpt

BACKGROUND: Psoriasis (PS) and metabolic syndrome (MetS) frequently co-occur. Characterizing their shared genetic architecture and spatially enriched cellular populations may clarify the context of their co-occurrence and generate hypotheses for functional validation. METHODS: We integrated genome-wide association study (GWAS) summary statistics for PS, MetS, and five related components with spatially resolved...

Read the complete abstract on PubMed

Topics

Psoriasis
Metabolic Syndrome
Genome-Wide Association Study
Humans
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Linkage Disequilibrium

Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 42743333
DOI: 10.1371/journal.pone.0358472
PMCID: PMC13577535

Genes

TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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