Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets

Abstract excerpt

Psoriasis is a heritable, common chronic autoimmune disorder characterized by cycles of remission and flare-ups. Here, we jointly analyze genomic and single-cell transcriptomic data to elucidate the genetic and molecular architecture of psoriasis. We perform a large-scale genome-wide meta-analysis of individuals of European ancestry (n = 1,131,685) and identify 125 independent susceptibility loci associated with p...

Topics

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• Chemokine receptors and signaling
• Psoriasis: Treatment and Pathogenesis
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

f7d229a5-6dde-57e9-b903-1988da11a9a9

DOI

10.1038/s41467-026-77309-2