Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.

doi:10.1038/s41467-026-77309-2

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Article

Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.

Nature communications - 27 Aug 2026

Jo Hyeonbin, Ahn Yeeun, Kim Beomsu, Song Minku, Shim Injeong, Kim Soyeon, Kim Hoyoung, Hong Sanghoon, Park Woong-Yang, Won Hong-Hee

Abstract excerpt

Psoriasis is a heritable, common chronic autoimmune disorder characterized by cycles of remission and flare-ups. Here, we jointly analyze genomic and single-cell transcriptomic data to elucidate the genetic and molecular architecture of psoriasis. We perform a large-scale genome-wide meta-analysis of individuals of European ancestry (n = 1,131,685) and identify 125 independent susceptibility loci associated with...

Read the complete abstract on PubMed

Topics

Humans
Psoriasis
Genome-Wide Association Study
Single-Cell Analysis
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Keratinocytes

Polymorphism, Single Nucleotide

Single-Cell Gene Expression Analysis

Transcriptome

T-Lymphocytes

Gene Expression Profiling

Endothelial Cells

Myeloid Cells

Source

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Identifiers

PMID: 42802183
DOI: 10.1038/s41467-026-77309-2
PMCID: PMC13616972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Oct 2026.