Article
Estimating selection on synonymous codon usage from noisy experimental data.
Molecular biology and evolution - 1 Jun 2013
Wallace Edward W J, Airoldi Edoardo M, Drummond D Allan
Abstract excerpt
A key goal in molecular evolution is to extract mechanistic insights from signatures of selection. A case study is codon usage, where despite many recent advances and hypotheses, two longstanding problems remain: the relative contribution of selection and mutation in determining codon frequencies and the relative contribution of translational speed and accuracy to selection. The relevant targets of selection--the...
Topics
- Codon
- Evolution, Molecular
- Gene Expression
- Models, Genetic
- Mutation
- Protein Biosynthesis
- Ribosomes
- Saccharomycetales
- Selection, Genetic