Genome-wide association study identifies toll-like receptor four protein-mediated metabolic remodelling affecting gout pathogenesis.

Abstract excerpt

Background: Obesity is a major risk factor for gout, but the biological mechanisms linking adiposity to crystal-driven inflammation remain largely unknown. Identifying genetic mediators of this relationship is crucial for developing targeted therapies. Methods: We conducted an integrative multi-omics study anchored by observational analysis of 9,700 adults from the National Health and Nutrition Examination Survey...

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