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Article

Mendelian randomization implicates circulating plasma proteins in gout risk and identifies candidate therapeutic targets.

International journal of immunopathology and pharmacology - 1 Jan 2026

Zhang Han, Dang Zixian, Yu Pixue, Chen GuanHong, Zhang Yingze, Wang Tianrui, Yu Tengbo, Zhang Yongtao, Shang Zhen

Abstract excerpt

OBJECTIVE: To explore whether circulating plasma proteins have potential causal effects on gout risk by integrating genome-wide association study (GWAS) data with protein quantitative trait loci (pQTL) information, aiming to identify candidate proteins and pathways for therapeutic targeting. INTRODUCTION: Despite advances in gout pathophysiology, personalized therapies and validated drug targets remain limited....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41885234
DOI: 10.1177/03946320261428859
PMCID: PMC13031745

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CPQ
FN1
PLAU
SPOCK2

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