Article
Shared Genetic Risk Between Acute Pancreatitis and Metabolic Syndrome Converges on a BCAT1-Positive Fibroblast Subpopulation and MAPK14-Driven Inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Jul 2026
Zhou Xiaoying, Yang Chen, Zou Tongxin, Basharat Zarrin, Zippi Maddalena, Fiorino Sirio, Hong Wandong
Abstract excerpt
Metabolic syndrome (MetS) has been associated with increased acute pancreatitis (AP) severity. This study aimed to identify shared differentially expressed genes (CDEGs) between MetS and AP and to prioritize mechanistically relevant targets. The shared genetic basis and causal effect of MetS on AP were first assessed using linkage disequilibrium score regression (LDSC) and two-sample Mendelian randomization (MR)....
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